Analysing development to shape the future

This article links theory and politics in a systematic way by proposing Is-Shall-Do as a didactical model for analysing a concrete conjuncture, relating it to the desired future in the form of a concrete utopia. Aware of structural limits and potential space of manoeuvre for political agency adequate practical steps to implement the concrete utopia are elaborated. The paper is divided in a first section which exposes three interwoven aspects of development: the the idea of a good life, the complexity and multi-dimensionality of development and the relationship of knowledge and power. Section two exposes the model of Is-Shall-Do abstractly, while section 3 exemplifies it by exposing the challenges for the European left. The analysis of conjuncture as a concrete analysis of a concrete situation is centred in Europe today on the topic of inequality produced by finance-based accumulation. As the concrete utopia of a good life , the authors propose the values of the French revolution, freedom, equality and solidarity which are unfulfilled promises of European development. The paper ends with a plea for organising democratic and egalitarian alternatives. (...) (authors' abstract)Series: SRE - Discussion Paper

Motives and influencing factors of corporate regional engagement: industry and company specific patterns

Traditionally, regional endowments are viewed as external variables when it comes to location choices of companies. In most concepts on location choices and regional economics companies are thought to view the local labour market, the local innovation system or the general quality of life in a region as given and chose the location that best suits the company’s needs. Increasingly however, scholars from different research fields are providing arguments to reverse that view and show that there can be good reasons for a company to engage in improving its location despite implicit externalities. In this paper we try to systematically analyse issue of corporate engagement in regions. We will show how strong and in which fields companies engage in their respective region, how this engagement can be related to their existing regional integration and what differences appear between industries and types of companies in this respect. In this study we draw upon extensive interviews with over thirty companies from three industrial sectors in the Austrian region of Styria: the metals industry, which dates back to medieval times and has gone through a deep process of economic restructuring, the automotive industry, the first industry in which a comprehensive cluster policy approach was applied in Austria and the software industry, a rather young industry that experienced high growth rates in the past years. We will conclude that even though there are differences between the industries and types of companies in terms of scope and scale of regional integration and regional engagement, there is a strong correlation between the two: the higher the regional integration, the higher corporate regional engagement and vice versa.

Von Innovationsnetzen, Ausbildungsprogrammen und Sportvereinen

Kulturelle Aspekte, wie die Einbettung in und das Engagement von Unternehmen für die Region, werden heute als zentrale Faktoren fürdie regionale Entwicklung betrachtet. Wie stark und in welchen Bereichen engagieren sich Unternehmen wirklich und bestehen Unterschiedezwischen Sektoren und Unternehmenstypen

53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process

Chromosome missegregation acts as one of the driving forces for chromosome instability and cancer development. Here, we find that in human cancer cells, HeLa and U2OS, depletion of 53BP1 (p53-binding protein 1) exacerbates chromosome non-disjunction resulting from a new type of sister-chromatid intertwinement, which is distinct from FANCD2-associated ultrafine DNA bridges (UFBs) induced by replication stress. Importantly, the sister DNA intertwinements trigger gross chromosomal rearrangements through a distinct process, named sister-chromatid rupture and bridging. In contrast to conventional anaphase bridge-breakage models, we demonstrate that chromatid axes of the intertwined sister-chromatids rupture prior to the breakage of the DNA bridges. Consequently, the ruptured sister arms remain tethered and cause signature chromosome rearrangements, including whole-arm (Robertsonian-like) translocation/deletion and isochromosome formation. Therefore, our study reveals a hitherto unreported chromatid damage phenomenon mediated by sister DNA intertwinements that may help to explain the development of complex karyotypes in tumour cells

Towards regional knowledge economics. Routes and policy options.

In recent years a move towards knowledge economies has been observed in many advanced countries. Knowledge based sectors and related activities have been expanding rapidly. However, the preconditions for developing such activities differ strongly between types of regions, depending on their location conditions, firm structure and institutional fabric. The regional innovation systems (RIS) approach captures such different settings in a useful way, allowing us to distinguish e.g. between well endowed and networked, fragmented and thin RIS. Using this approach we will study which conditions, potentials and barriers exist in different types of RIS for developing knowledge based industries and activities, and which routes and policy options might be adequate in different regional settings. We investigate these questions at first conceptually, drawing on the literature on RIS, and location and clustering of knowledge based sectors. Empirically we will present evidence on three regions in Austria (Vienna, Upper Austria and Salzburg) representing different types of RIS. Based on the conceptual findings we will compare these regions regarding their RIS characteristics, their preconditions for and strengths of knowledge based sectors focussing in particular on the ICT sector. Furthermore we will analyse routes and policy options for developing knowledge based sectors for such different types of regions. (author´s abstract)Series: SRE - Discussion Paper

Motives and influencing factors of corporate regional engagement. Industry and company specific patterns.

Traditionally, regional endowments are viewed as external variables when it comes to location choices of companies. In most concepts on location choices and regional economics companies are thought to view the local labour market, the local innovation system or the general quality of life in a region as given and chose the location that best suits the company's needs. Increasingly however, scholars from different research fields are providing arguments to reverse that view and show that there can be good reasons for a company to engage in improving its location despite implicit externalities. In this paper we try to systematically analyse issue of corporate engagement in regions. We will show how strong and in which fields companies engage in their respective region, how this engagement can be related to their existing regional integration and what differences appear between industries and types of companies in this respect. In this study we draw upon extensive interviews with over thirty companies from three industrial sectors in the Austrian region of Styria: the metals industry, which dates back to medieval times and has gone through a deep process of economic restructuring, the automotive industry, the first industry in which a comprehensive cluster policy approach was applied in Austria and the software industry, a rather young industry that experienced high growth rates in the past years. We will conclude that even though there are differences between the industries and types of companies in terms of scope and scale of regional integration and regional engagement, there is a strong correlation between the two: the higher the regional integration, the higher corporate regional engagement and vice versa.Series: SRE - Discussion Paper

The Vienna software cluster: local buzz without global pipelines?

The goal of this paper is to examine innovation activities in the Vienna software industry and to get a better understanding of the nature and geography of knowledge linkages in this sector. In the literature there seems to be a growing consensus that innovation rests on both informal local knowledge linkages and formal global networks, i.e. a combination of "local buzz" and "global pipelines". Recent studies on the software sector, however, show that the importance of different types of knowledge sources, the spatial dimension of knowledge transfer and the relevance of different channels of knowledge exchange in the software industry remain poorly understood. Drawing on a firm survey and qualitative face-to-face interviews with companies we will show that in the Vienna software industry the transfer and exchange of knowledge is highly localised and strongly informal in nature, pointing to a high significance of "local buzz" and a lack of "global pipelines". This specific pattern raises the question whether the Vienna software sector is exposed to a danger of lock in. (author´s abstract)Series: SRE - Discussion Paper

Innovation and knowledge sourcing in the Vienna ICT manufacturing sector

The aim of this paper is to investigate the nature and geography of innovation and knowledge sourcing activities in the ICT manufacturing sector in the region of Vienna. Vienna is often regarded as a prime example of a fragmented metropolitan regional innovation system. Fragmented regional innovation systems are characterised by a strong endowment with knowledge infrastructure elements and other innovation relevant institutions, but they suffer from a lack of local networking and knowledge circulation. In this paper we examine for Vienna whether this key deficiency of the regional innovation system, i.e. fragmentation, is also a crucial feature of knowledge based sectors such as the ICT manufacturing industry which exhibit an analytical knowledge base. Drawing on 18 face-to- face interviews with firms and an analysis of 207 knowledge links and 264 knowledge transfer channels we will show that local collective learning processes are vital for innovative companies in the Vienna ICT manufacturing sector, whilst at the same time they rely heavily on international knowledge sources. The significance of the local level as interaction space for knowledge exchange found in the ICT manufacturing sector indicates that at least for this knowledge based industry, Vienna's innovation system is of a less fragmented nature than previous studies have suggested. Knowledge based sectors are characterised by a high level of localised knowledge circulation which underpins radical innovation. (authors' abstract)Series: SRE - Discussion Paper

Vienna in an emerging trans-border region. Socioeconomic development in Central Europe.

Drawing upon a periodisation of socio-economic development based on the regulation approach, the paper conducts a historical spatial development analysis of Vienna in its broader territory and multi-level perspective. The National context and the East-West cleavages mark the geography of the study. This periodisation is the basis to understand the strategies of Vienna in changing territorialities, the social forces and discourses that are reflected in the present context of Europeanisation, internationalisation and integration of border regions. A critical institutionalist approach is used to analyse the hegemonic liberal and populist discourses and strategies. The lessons taken in this section build the path to outline windows of opportunity for progressive politics, which are sketch out in the last section of the article. The ideas exposed in the paper are partial results of broader research carried out in the frame of DEMOLOGOS, an EU financed project. (authors' abstract)Series: SRE - Discussion Paper

Sozioökonomische Veränderungen in der Vienna Region 1971-2001. Ausgewählte Ergebnisse.

Series: SRE - Discussion Paper